Efficiency of Clustering Algorithms in Mining Biological databases Research Paper

Efficiency of Clustering Algorithms in Mining Biological databases - Research Paper Example For example Hierarchical algorithms often work by either splitting or merging the groups being analyzed in order to develop a hierarchy of clusters that is based on the similarity of the sequences. On the other hand, partitioning algorithms work by partitioning the data sets being analyzed based on distance between them (Fayyad , 2003, 346). The selection of any type of clustering algorithm should however be primarily based on the nature of the sequences or clusters to be analyzed, the acceptable error expected as the availability of computational resources. This is particularly with regard to the fact that each of the categories of clustering algorithms has its own strengths and limitations and therefore suited for different tasks. Biological databases such as those involving the mining of protein or gene sequences are best analyzed using clustering algorithms because it provides detailed exploratory analysis of the sequences. This paper critically analyzes the efficiency of cluster ing algorithms in the mining of biological databases such as gene sequences. Applications of clustering algorithms in analyzing gene sequences During the statistical analysis of biological databases, the choice of clustering, the choice of clustering algorithm often depends on the nature of data sets as well as the intended application of the results. In biological data mining most of the sequences that are increasingly being analyzed using clustering algorithms include genomic as well as protein sequences. According to Werner (2008, 52), recent advances in bioinformatics have resulted in the increasing use of clustering algorithms in the analysis of both protein and gene sequences In the study of gene expressions, clustering is one of the major exploratory techniques used in the analysis of microarray slides containing hundreds of thousands of genes2. In such cases, clustering is employed to help group together similar genes and consequently enable the biologists to identify the re lationship between the particular genes as well as reduce the amount of information that is needed to be analyzed. Genes clustered together are usually co-regulated or sharing similar functions. Additionally when time series clustering methods are used, genes which exhibit similar characteristics at given times may be grouped together to indicate a possibility of co-regulation. Clustering algorithms can also be efficiently used analyze gene samples on the basis of similar expression patterns. Although expression patterns usually involve complex phenotypes, clustering analysis is one of the most effective techniques that can be used to identify arrays with similar or different phenotype characteristics. This application of clustering algorithms is particularly important in medical researches where the approach allows medical scientists to identify different pathologies on the basis of the gene expression patterns as opposed to the common histological methods. In unsupervised cluster analysis of gene expression arrays, the major assumption is usually that genes of the same biological process should be clustered together whether in condition dependent or in time series. Another important area in the mining of genetic databases in which clustering algorithms is significantly used is the analysis of gene profiles. In this regard clustering algorithm is potentially important in the analysis of sub classes of diseases as well as in the detection of genes

Conrad's Vision of the colonial world in nostromo and the heart of Essay

Conrad's Vision of the colonial world in nostromo and the heart of darkness - Essay Example There are also diverse political systems within the country, look at http://www.123helpme.com/assets/16087.html for more information. Enslavement of congo in 1800 brought many changes to the country with suppression of rights of the inhabitants and pauperization of their lives. What will help a lot is reading the biography of the author and understanding for political viewpoints and ethical standpoints to use it for the interview. Based on his biography you can give detailed explanation of why he used each symbol in his works. The main idea here is to make a contradiction between the two pieces of work. Finding common and dissimilar ideas you convey that you have fully understood what the author is trying to show through his work. He was born shortly after the Crimean war in Poland and both his father and his mother died of tuberculosis so he had to lie with his uncle. Using the fact that he left his country to avoid "being conscripted for service in the Russian army" you can see that the suppression element drove him out of his beloved country. He t ravelled to France and England and he went to Congo which fascinated him. There is here therefore a love for the setting of his work which he would most certainly not like to see under the suppression of any country. This bias is a setting for the elements of his work. The second thing you need to focus on are the characters of the two pieces of work. ... mainly in the central character and the other central characters that are in the setting is what is missing from the author's life or the kind of people they highly appreciate and miss. In any case when evaluating a piece of literature work one needs to keep in mind that even though the author is trying to convey personal convictions each literature piece is interpreted differently by the author There is no right or wrong in a literature piece, however all the elements of the piece, setting, characters, ethics, author bio etc. need to be taken into consideration to have a COMPLETE view of the piece of work and have a personal viewpoint of everything included in the work. What you might also need to do is probably memorise what is said in some parts of the text because this will convince for sure your professors that you have written the dissertation. In every academic paper details make the difference and they are always giving extra mark. Try referring to specific characters for ins tance. As far as the setting is concerned you will also need to keep in mind the political situation when the author was born and make a correlation between that and the political situation in the two works. You need to remember that you cannot focus on EVERYTHING that is considered important. You will need to extract what you think was most important for you and elaborate on this but really learn a lot of details. Your professors will read your paper and they will focus on what contradicitions are made and they will ask you questions on these. They might also ask what you mean by some sentences in your dissertation so be prepared to answer any vague points. 2. The characters of the works The second thing that need to be stressed are the main characters in Nostromo, you have Gould who